A Multicenter Randomized Controlled Study of Preoperative Oral Administration of Branched-chain Amino Acids in Reducing Postoperative Insulin Resistance in Colorectal Cancer Patients

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Postoperative insulin resistance refers to the phenomenon that the body's glucose uptake stimulated by insulin is reduced due to stress effects such as trauma or the inhibitory effect of insulin on liver glucose output is weakened after surgery. There is a clear link between postoperative insulin resistance and poor perioperative prognosis. Therefore, exploring interventions to reduce postoperative stress insulin resistance, stabilize postoperative blood glucose, and reduce postoperative complications are clinical problems that need to be solved urgently. In recent years, research on branched-chain amino acids and metabolic diseases has become a hot spot. Studies have found that in the rat model, preoperatively given a high branched-chain amino acid diet can inhibit postoperative insulin resistance and stabilize blood glucose levels. This research plan is to try to add branched-chain amino acids before surgery to observe the occurrence of postoperative insulin resistance in patients.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 80
Healthy Volunteers: f
View:

• Age 50-80 years old ;

• Clinical diagnosis of colorectal cancer;

• Planned elective laparoscopic radical resection of colorectal cancer;

• Preoperative American Society of Anesthesiologists(ASA)score grade I-III ;

• Informed consent was obtained from patients.

Locations
Other Locations
China
Shanghai Tongren Hospital
RECRUITING
Shanghai
Contact Information
Primary
Peng Sun, MD
SP2082@shtrhospital.com
+86-18121225835
Backup
Hengyu Lv
LHY4624@shtrhospital.com
+86-18006315921
Time Frame
Start Date: 2022-08-26
Estimated Completion Date: 2024-12
Participants
Target number of participants: 224
Treatments
Experimental: research group
600ml drink which contains 18g BCAA was consumed by patients 2-4h before surgery.
Placebo_comparator: control group
600ml water was consumed by patients 2-4h before suegery.
Related Therapeutic Areas
Sponsors
Collaborators: Yangpu District Central Hospital Affiliated to Tongji University, Huashan Hospital
Leads: Sun Peng

This content was sourced from clinicaltrials.gov